General Information

  • ID:  hor001351
  • Uniprot ID:  A0A6J3BTT9
  • Protein name:  Gam-Neuropeptide F
  • Gene name:  LOC113523523
  • Organism:  Galleria mellonella (Greater wax moth)
  • Family:  MADD family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Galleria (genus), Galleriinae (subfamily), Pyralidae (family), Pyraloidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0016301 kinase activity
  • GO BP:  GO:0006915 apoptotic process; GO:0016310 phosphorylation
  • GO CC:  GO:0005737 cytoplasm; GO:0005886 plasma membrane; GO:0016020 membrane

Sequence Information

  • Sequence:  AMVRF
  • Length:  5
  • Propeptide:  MDIQKQHLCPRLVDYLTIVGARPYTSGKGLAPVQAPELLRRYPLTNHNDFPLPLDMVYFCQPEGCVSVGPRRTPSHLATRDTTSFVFTLTDKDSGKTRYGICVNFYRAVERAPAPGPRERSMLRRESWRKSMEKSSDSAFSSDYRSSNVAPSDSERDCSATLGPRLAAAPDSESGGSHSPSPRATRKRQRIRNHSLTSLCLLSHHPFFSTFRECLFILKKLIDACNESSSPRRVGASRQIFRDTVWSVLTGQAYDNTPTIVLHDVKEIETWILRLLSAPVPVPGKTRIELEVLSPTAHAPLLFALPDHTRFALVDFPLHLPLELLGVDTCLKVLTLILLENKVVVQSRDYNALSMSVMALVAMLYPLEYMFPAIPLLPSCMSCAEQLLLAPTPFLIGIPATFLTYKKNFRLPDDIWLVDLDATKLISPTGNDQDLPPLPEPEGSVLKNHLKQAMQLMGSAGAGALSSLTNSTAEQATALLMPSRRDSVGGATLKVQQASFRSSSDGAQSAPHSTPESRRVSLGGGGGAASAGHTPQRLSLASPHQPHQPHQGQPFNPLIYGNDVDSVDVATRVAMVRFFNSQNILANFMEHTRTLRLYPRPVVAFQINSFLRSRPRTTSFLNKFARTQAVEFLAEWSLTPCNVAFLRVQTGVFDPRQIGDKPKWFADTLQPIRFAVWDDGSSLNGALRQLQRQENQPTDESGSDSEAAESTSSSYSSLSDFVSEMVSSDLSPGGNHQHVIGETYSAVVQVPMTLSSSLDPKTVYSPPSSLLFGEEAEAGEGGERGTGRESTSPSPSPSSSEHSELSDDEPPARDHAPRDHPLPVKKSDTDSGSFGRESDSNSTTTPKTVVSRQRAAADSASTSDSERALTPSHASLASVSASAPASASASASHVPSHHSHVKSTSSGVSRQASQTSLLEQFAAQAKELVRETTRQSSQEGILAHMDKKGKVADGEDKKIFAPFGQLTLHAKKAAEEASKSMQEASKTALEASKTATAVSKNTFEDLTYVSKSTFGDLTKSAKEAAAKKGLLIKGESQDLPGGVNARRDSTALQTTNLLTATHRDFFSNISSDLNGLAASTSSMFSDFFGSKGKQAKPGEAGRGAAAAGGAAGGAAAGGLVQHVLEGEGVGWLKLNRLKKLMEDESYRNMVLSKLNRNFNRKATPSDKVDDVFISKPVWKGMLKVLQAVVHGLEHTYSNFGLGGMASVFQLAEMAHTHYWSKELAALDGAGASAAAAAAALLDYRHDLDTPSSSSPSSRKSSQPDIPIVNYPDMDSSEAQSTTEMFKDMLNQKRNFLFSKLTSFDSDAAPSSDCSADESGSITTNRANLFDHRASFKSNLSDTDVMFLNVGRGGGGKPRASSVFSSKSSLGYRPPPPVGVPVTSPLTSPETARTYLFQGLIGKERSNLWDQMQFWEDAFLDAVSQERDMIGMDQGANEMMERYKCLSETERKRTIVERWWYERLVNMTYSPKIRVLCLWRKCGGQTQLHKYYTKKCKALYYCIKEAMEKSGRRQDAAELGGEFPIQDCATGEGGLIQVCMEGVGLLFHHSKDFEFFVRLDHIRKCFTQNGGIFVLEEFNPKTRQILQRKYKSIMAEKVVLDLHRFFSIWLSRYFVETHGTQLHYAPYVS
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001351_AF2.pdbhor001351_ESM.pdb

Physical Information

Mass: 69431 Formula: C28H46N8O6S
Absent amino acids: CDEGHIKLNPQSTWY Common amino acids: AFMRV
pI: 10.55 Basic residues: 1
Polar residues: 0 Hydrophobic residues: 3
Hydrophobicity: 124 Boman Index: -374
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 800 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  15706623
  • Title:  Mass Spectrometric Analysis of Head Ganglia and Neuroendocrine Tissue of Larval Galleria Mellonella (Arthropoda, Insecta)